Participate in a Clinical Trial
Without the participation of people with MS, it would be impossible to develop new and better therapies and other interventions.
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
Study Purpose
This is a randomized, double blind, controlled, parallel group, multicenter study to evaluate efficacy, safety and pharmacokinetics of a higher dose of ocrelizumab per intravenous (IV) infusion every 24 weeks in participants with RMS, in comparison to the approved 600 mg dose of ocrelizumab.
Recruitment Criteria
Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms |
No |
Study Type
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes. Searching Both is inclusive of interventional and observational studies. |
Interventional |
Eligible Ages | 18 Years - 55 Years |
Gender | All |
More Inclusion & Exclusion Criteria
Inclusion Criteria:
- - Diagnosis of relapsing multiple sclerosis (RMS) (i.e., RRMS or aSPMS where participants still experience relapses) in accordance with the revised McDonald Criteria 2017.
- - At least two documented clinical relapses within the last 2 years prior to screening, or one clinical relapse in the year prior to screening.
- - Participants must be neurologically stable for at least 30 days prior to randomization and baseline.
- - Expanded disability status scale (EDSS) score, at screening and baseline, from 0 to 5.5 inclusive.
- - Average T25FWT score over two trials at screening and over two trials at baseline respectively, up to 150 (inclusive) seconds.
- - Average 9HPT score over four trials at screening and over four trials at baseline respectively, up to 250 (inclusive) seconds.
- - Documented MRI of brain with abnormalities consistent with MS at screening.
- - Participants requiring symptomatic treatment for MS and/or physiotherapy must be treated at a stable dose.
- - For females of childbearing potential, agreement to remain abstinent or use adequate contraceptive methods.
- - For female participants, without reproductive potential may be enrolled if post-menopausal, unless receiving a hormonal therapy for her menopause or if surgically sterile.
Exclusion Criteria:
- - History of primary progressive MS at screening.
- - Any known or suspected active infection at screening or baseline (except nailbed infections), or any major episode of infection requiring hospitalization or treatment with IV antimicrobials within 8 weeks or treatment with oral antimicrobials within 2 weeks, prior to and during screening.
- - History of confirmed or suspected progressive multifocal leukoencephalopathy.
- - History of cancer, including hematologic malignancy and solid tumors, within 10 years of screening.
- - Immunocompromised state.
- - Receipt of a live or live-attenuated vaccine within 6 weeks prior to randomization.
- - Inability to complete an MRI or contraindication to gadolinium administration.
- - Contraindications to mandatory pre-medications for IRRs.
- - Known presence of other neurologic disorders that could interfere with the diagnosis of MS or assessments of efficacy and/or safety during the study.
- - Any concomitant disease that may require chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study.
- - Significant, uncontrolled disease that may preclude participant from participating in the study.
- - History of or currently active primary or secondary, non-drug-related, immunodeficiency.
- - Pregnant or breastfeeding or intending to become pregnant.
- - Lack of peripheral venous access.
- - History of alcohol or other drug abuse within 12 months prior to screening.
- - Treatment with any investigational agent within 24 weeks prior to screening or treatment with any experimental procedure for MS.
- - Previous use of anti-CD20s (including ocrelizumab), unless the last infusion was more than 2 years before screening, B-cell count is normal, and the stop of the treatment was not motivated by safety reasons or lack of efficacy.
- - Previous treatment with fingolimod, siponimod, or ozanimod within 6 weeks of baseline.
- - Previous treatment with natalizumab within 4.5 months of baseline.
- - Previous treatment with interferons beta (1a or 1b), or glatiramer acetate within 2 weeks of baseline.
- - Any previous treatment with mitoxantrone, cladribine, atacicept, alemtuzumab, and daclizumab.
- - Previous treatment with any other immunomodulatory or immunosuppressive medication not already listed above without appropriate washout as described in the applicable local label.
- - Any previous treatment with bone marrow transplantation and hematopoietic stem cell transplantation.
- - Any previous history of transplantation or anti-rejection therapy.
- - Treatment with intravenous (IV) immunoglobulin (Ig) or plasmapheresis within 12 weeks prior to randomization.
- - Systemic corticosteroid therapy within 4 weeks prior to screening.
- - Positive screening tests for active, latent, or inadequately treated hepatitis B.
- - Sensitivity or intolerance to any ingredient (including excipients) of ocrelizumab.
- - Any additional exclusionary criterion as per ocrelizumab local label, if more stringent than the above.
Trial Details
Trial ID:
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries. |
NCT04544436 |
Phase
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans. Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data. Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use. |
Phase 3 |
Lead Sponsor
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data. |
Hoffmann-La Roche |
Principal Investigator
The person who is responsible for the scientific and technical direction of the entire clinical study. |
Clinical Trials |
Principal Investigator Affiliation | Hoffmann-La Roche |
Agency Class
Category of organization(s) involved as sponsor (and collaborator) supporting the trial. |
Industry |
Overall Status | Recruiting |
Countries | Argentina, Australia, Belgium, Brazil, Canada, Czechia, Denmark, France, Germany, Greece, Hungary, Israel, Italy, Mexico, Netherlands, Peru, Poland, Portugal, Russian Federation, Spain, Switzerland, Turkey, Ukraine, United Kingdom, United States |
Conditions
The disease, disorder, syndrome, illness, or injury that is being studied. |
Multiple Sclerosis |
Additional Details
Participants will be treated for a minimum of 120 weeks in the double-blind phase. Upon positive primary results after the double-blind phase, an optional higher dose extension treatment (OLE phase) is planned for eligible participants. The OLE will be carried out for approximately 96 weeks. Participants will be followed for safety for 48 weeks thereafter. Participants whose B-cell levels still did not replete to their baseline level or the low level of normal (LLN), whichever is lower, will move into the B-cell monitoring (BCM) phase following the safety follow-up phase. The study will end when all participants who were not treated with an alternative B-cell depleting therapy have repleted their B-cells to the baseline value or the lower limit of normal.
Arms & Interventions
Arms
Experimental: Ocrelizumab Higher Dose
Participants will be randomized to receive a minimum of 5 higher treatment doses (1200 mg or 1800 mg) of ocrelizumab administered by intravenous (IV) infusion every 24 weeks in the double blind treatment (DBT) phase. During the optional open-label extension (OLE) phase, participants will continue with their assigned dose of ocrelizumab (either 1200 or 1800 mg) for approximately 96 weeks (4 doses in total). Mandatory methylprednisolone (or equivalent) and antihistaminic drug (e.g., diphenhydramine or equivalent) will be administered approximately 30-60 minutes prior to the start of each ocrelizumab infusion.
Active Comparator: Ocrelizumab Approved Dose
Participants will be randomized to receive a minimum of 5 treatment doses of 600 mg ocrelizumab administered by intravenous (IV) infusion every 24 weeks in the DBT phase. During the optional OLE phase, participants will be offered a higher dose of ocrelizumab (either 1200 or 1800 mg), based on their body weight at OLE baseline, for approximately 96 weeks (4 doses in total). Mandatory methylprednisolone (or equivalent) and antihistaminic drug (e.g., diphenhydramine or equivalent) will be administered approximately 30-60 minutes prior to the start of each ocrelizumab infusion.
Interventions
Drug: - Ocrelizumab
The actual higher dose of ocrelizumab will be assigned to participants based on their body weight at baseline: 1200 mg (participants's body weight <75 kg) or 1800 mg (participant's body weight >/=75 kg). The first dose of ocrelizumab will be administered as two 600 mg or 900 mg intravenous (IV) infusions given 14 days apart. For the subsequent doses, ocrelizumab will be administered as a single 1200 mg or 1800 mg IV infusion every 24 weeks.
Drug: - Ocrelizumab
Ocrelizumab will be administered at a dose of 600 milligram (mg) every 24 weeks. The first dose of ocrelizumab will be administered as two 300 mg intravenous (IV) infusions given 14 days apart. For the subsequent doses, ocrelizumab will be administered as a single 600 mg IV infusion every 24 weeks.
Drug: - Antihistamine
Premedication with oral or IV antihistaminic drug (i.e., diphenhydramine 50 mg or an equivalent dose of an alternative) will be administered prior to each ocrelizumab infusion.
Drug: - Methylprednisolone
Premedication with 100 mg of methylprednisolone (or equivalent) will be administered by IV infusion prior to each ocrelizumab infusion.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.
North Central Neurology Associates, Cullman, Alabama
Status
Active, not recruiting
Address
North Central Neurology Associates
Cullman, Alabama, 35058
Alabama Neurology Associates, Homewood, Alabama
Status
Active, not recruiting
Address
Alabama Neurology Associates
Homewood, Alabama, 35209
21st Century Neurology, Phoenix, Arizona
Status
Active, not recruiting
Address
21st Century Neurology
Phoenix, Arizona, 85004
North County Neurology Associates, Carlsbad, California
Status
Active, not recruiting
Address
North County Neurology Associates
Carlsbad, California, 92011
Sacramento, California
Status
Withdrawn
Address
University of California Davis Medical Center
Sacramento, California, 95817
Stanford, California
Status
Active, not recruiting
Address
Stanford University Medical Center; Stanford Neuroscience Health Center
Stanford, California, 94305
Collaborative Neuroscience Network Inc., Torrance, California
Status
Completed
Address
Collaborative Neuroscience Network Inc.
Torrance, California, 90502
Basalt, Colorado
Status
Completed
Address
Mountain Neurological Research Center; Roaring Fork Neurologt, P.C.
Basalt, Colorado, 81621
Colorado Neurological Institute, Englewood, Colorado
Status
Withdrawn
Address
Colorado Neurological Institute
Englewood, Colorado, 80113
Advanced Neurology of Colorado, LLC, Fort Collins, Colorado
Status
Active, not recruiting
Address
Advanced Neurology of Colorado, LLC
Fort Collins, Colorado, 80528
SFM Clinical Research, LLC, Boca Raton, Florida
Status
Withdrawn
Address
SFM Clinical Research, LLC
Boca Raton, Florida, 33487
Clearwater, Florida
Status
Withdrawn
Address
MS and Neuromuscular Center of Excellence
Clearwater, Florida, 33761
Maitland, Florida
Status
Active, not recruiting
Address
Neurology Associates, PA; Research Department
Maitland, Florida, 32751
University of South Florida, Tampa, Florida
Status
Active, not recruiting
Address
University of South Florida
Tampa, Florida, 33612
Shepherd Center Inc., Atlanta, Georgia
Status
Withdrawn
Address
Shepherd Center Inc.
Atlanta, Georgia, 30309
Consultants in Neurology Ltd, Northbrook, Illinois
Status
Withdrawn
Address
Consultants in Neurology Ltd
Northbrook, Illinois, 60062
American Health Network Institute, LLC, Avon, Indiana
Status
Active, not recruiting
Address
American Health Network Institute, LLC
Avon, Indiana, 46123
University of Kansas Medical Center, Kansas City, Kansas
Status
Active, not recruiting
Address
University of Kansas Medical Center
Kansas City, Kansas, 66160
Alexandria, Louisiana
Status
Active, not recruiting
Address
The NeuroMedical Clinic of Central Louisiana
Alexandria, Louisiana, 71301
Maine Medical Center, Scarborough, Maine
Status
Recruiting
Address
Maine Medical Center
Scarborough, Maine, 04074
Massachusetts General Hospital., Boston, Massachusetts
Status
Withdrawn
Address
Massachusetts General Hospital.
Boston, Massachusetts, 02114
Dragonfly Research, LLC, Wellesley, Massachusetts
Status
Active, not recruiting
Address
Dragonfly Research, LLC
Wellesley, Massachusetts, 02481
Detroit, Michigan
Status
Withdrawn
Address
Wayne State University; Department of Neurology
Detroit, Michigan, 48201
Henry Ford Health System, Detroit, Michigan
Status
Active, not recruiting
Address
Henry Ford Health System
Detroit, Michigan, 48202
Washington University School of Medicine, Saint Louis, Missouri
Status
Active, not recruiting
Address
Washington University School of Medicine
Saint Louis, Missouri, 63110
Las Vegas, Nevada
Status
Active, not recruiting
Address
Cleveland Clinic Lou Ruvo; Center for Brain Research
Las Vegas, Nevada, 89106
Dent Neurological Institute, Amherst, New York
Status
Active, not recruiting
Address
Dent Neurological Institute
Amherst, New York, 14226
Stony Brook University Medical Center, Stony Brook, New York
Status
Withdrawn
Address
Stony Brook University Medical Center
Stony Brook, New York, 11794
UC Health Neurology, Dayton, Ohio
Status
Active, not recruiting
Address
UC Health Neurology
Dayton, Ohio, 45417
Oklahoma City, Oklahoma
Status
Recruiting
Address
Oklahoma Medical Research Foundation; MS Center of Excellence
Oklahoma City, Oklahoma, 73104
Abington Neurological Associates, Abington, Pennsylvania
Status
Active, not recruiting
Address
Abington Neurological Associates
Abington, Pennsylvania, 19001
Tri-State Mountain Neurology, Johnson City, Tennessee
Status
Completed
Address
Tri-State Mountain Neurology
Johnson City, Tennessee, 37604
Hope Neurology, Knoxville, Tennessee
Status
Recruiting
Address
Hope Neurology
Knoxville, Tennessee, 37922
Bhupesh Dihenia M.D. P.A., Lubbock, Texas
Status
Active, not recruiting
Address
Bhupesh Dihenia M.D. P.A.
Lubbock, Texas, 79410
Central Texas Neurology Consultants, Round Rock, Texas
Status
Withdrawn
Address
Central Texas Neurology Consultants
Round Rock, Texas, 78681
Neurology Center of San Antonio, San Antonio, Texas
Status
Active, not recruiting
Address
Neurology Center of San Antonio
San Antonio, Texas, 78258
Evergreen MS Center, Kirkland, Washington
Status
Active, not recruiting
Address
Evergreen MS Center
Kirkland, Washington, 98034
International Sites
Buenos Aires, Argentina
Status
Active, not recruiting
Address
Centro de Especialidades Neurológicas y Rehabilitación - CENyR
Buenos Aires, , C1424
CEMIC, Buenos Aires, Argentina
Status
Active, not recruiting
Address
CEMIC
Buenos Aires, , C1431FWO
San Miguel, Argentina
Status
Active, not recruiting
Address
Centro de Investigaciones Médicas Tucuman; REUMATHOLOGY
San Miguel, , T4000AXL
Concord Repatriation General Hospital, Concord, New South Wales, Australia
Status
Withdrawn
Address
Concord Repatriation General Hospital
Concord, New South Wales, 2139
Specialists on College; Neurology, Kent Town, South Australia, Australia
Status
Withdrawn
Address
Specialists on College; Neurology
Kent Town, South Australia, 5067
Austin Hospital; Department of Neurology, Heidelberg, Victoria, Australia
Status
Active, not recruiting
Address
Austin Hospital; Department of Neurology
Heidelberg, Victoria, 3084
Hospital Erasme, Bruxelles, Belgium
Status
Active, not recruiting
Address
Hospital Erasme
Bruxelles, , 1070
CHU Tivoli, La Louvière, Belgium
Status
Withdrawn
Address
CHU Tivoli
La Louvière, , 7100
Revalidatie en MS Centrum, Overpelt, Belgium
Status
Active, not recruiting
Address
Revalidatie en MS Centrum
Overpelt, , 3900
Instituto de Neurologia de Curitiba, Curitiba, PR, Brazil
Status
Active, not recruiting
Address
Instituto de Neurologia de Curitiba
Curitiba, PR, 81210-310
IMV Pesquisa Neurológica, Porto Alegre, RS, Brazil
Status
Active, not recruiting
Address
IMV Pesquisa Neurológica
Porto Alegre, RS, 90110-000
Joinville, SC, Brazil
Status
Active, not recruiting
Address
Clinica Neurologica; Neurocirurgica de Joinville
Joinville, SC, 89202-190
CPQuali Pesquisa Clinica Ltda, Sao Paulo, SP, Brazil
Status
Active, not recruiting
Address
CPQuali Pesquisa Clinica Ltda
Sao Paulo, SP, 01228-000
Hospital das Clinicas - FMUSP, Sao Paulo, SP, Brazil
Status
Withdrawn
Address
Hospital das Clinicas - FMUSP
Sao Paulo, SP, 05403-900
Calgary, Alberta, Canada
Status
Withdrawn
Address
Foothills Medical Centre; Centre Dept of Medical Clinical Neuroscience
Calgary, Alberta, T2N 2T9
University of Alberta Hospital, Edmonton, Alberta, Canada
Status
Withdrawn
Address
University of Alberta Hospital
Edmonton, Alberta, T6G 1Z1
Burnaby, British Columbia, Canada
Status
Withdrawn
Address
Fraser Health Authority - Fraser Health Multiple Sclerosis
Burnaby, British Columbia, V5G 2X6
University of British Columbia, Vancouver, British Columbia, Canada
Status
Withdrawn
Address
University of British Columbia
Vancouver, British Columbia, V6T 1Z4
Ottawa, Ontario, Canada
Status
Withdrawn
Address
The Ottawa Hospital - General Campus; Department of Neurology - Multiple Sclerosis
Ottawa, Ontario, K1H 8L6
St. Michael'S Hospital, Toronto, Ontario, Canada
Status
Withdrawn
Address
St. Michael'S Hospital
Toronto, Ontario, M5B 1W8
Recherche Sepmus Inc., Greenfield Park, Quebec, Canada
Status
Completed
Address
Recherche Sepmus Inc.
Greenfield Park, Quebec, J4V 2J2
Chum Campus Notre Dame, Montreal, Quebec, Canada
Status
Withdrawn
Address
Chum Campus Notre Dame
Montreal, Quebec, H2X 0A9
Quebec City, Quebec, Canada
Status
Withdrawn
Address
Centre Hospitalier Affilie Universitaire de Quebec - Hopital de L'Enfant Jesus
Quebec City, Quebec, G1J 1Z4
Hotel-Dieu de Levis, Quebec, Canada
Status
Active, not recruiting
Address
Hotel-Dieu de Levis
Quebec, , G1W 4R4
Brno, Czechia
Status
Withdrawn
Address
Fakultni nemocnice u sv. Anny; Neurologicka klinika
Brno, , 656 91
Hradec Králové, Czechia
Status
Withdrawn
Address
Charles University, Medical faculty, Hradec Kralove ;Department of Neurology
Hradec Králové, , 500 05
Jihlava, Czechia
Status
Withdrawn
Address
Nemocnice Jihlava; NEU-Neurologicke oddeleni
Jihlava, , 58633
Pardubice, Czechia
Status
Withdrawn
Address
Krajska Nemocnice Pardubice Neurologicka Klinika
Pardubice, , 532 03
Vseobecna fakultni nemocnice v Praze, Praha 2, Czechia
Status
Withdrawn
Address
Vseobecna fakultni nemocnice v Praze
Praha 2, , 12808
Praha, Czechia
Status
Withdrawn
Address
Fakultni nemocnice Motol; Neurologicka klinika
Praha, , 150 06
Teplice, Czechia
Status
Withdrawn
Address
Nemocnice Teplice; Neurologicke Oddeleni - Ms Centrum
Teplice, , 415 29
Glostrup, Denmark
Status
Active, not recruiting
Address
Rigshospitalet Glostrup; Neurologisk Klinik
Glostrup, , 2600
Besançon, France
Status
Withdrawn
Address
CHU de Besancon Hopital Jean Minjoz; Service de Neurologie
Besançon, , 25030
Bordeaux, France
Status
Active, not recruiting
Address
Groupe Hospitalier Pellegrin; Service de Neurologie - 3ème étage
Bordeaux, , 33076
Brest, France
Status
Withdrawn
Address
CHU Brest Hopital La Cavale Blanche; Neurologie
Brest, , 29609
Caen, France
Status
Withdrawn
Address
Hopital Cote De Nacre; Unite Neurologie Generale
Caen, , 14033
Clermont Ferrand, France
Status
Active, not recruiting
Address
CHU Hopital Gabriel Montpied; Service de Neurologie
Clermont Ferrand, , 63003
CH St Vincent de Paul, Lille, France
Status
Active, not recruiting
Address
CH St Vincent de Paul
Lille, , 59000
Rouen, France
Status
Active, not recruiting
Address
Hôpital Charles Nicolle; Service de Neurologie
Rouen, , 76031
Charite - Universitätsmedizin Berlin, Berlin, Germany
Status
Active, not recruiting
Address
Charite - Universitätsmedizin Berlin
Berlin, , 12203
Bochum, Germany
Status
Active, not recruiting
Address
St. Josef-Hospital, Klinik für Neurologie
Bochum, , 44791
Bonn, Germany
Status
Withdrawn
Address
Gesundheitszentrum St. Johannes Hospital; Neurolog. Gemeinschaftspraxis Dres. Schmidt, Neudecker etc
Bonn, , 53111
Böblingen, Germany
Status
Withdrawn
Address
Studienzentrum für Neurologie und Psychiatrie
Böblingen, , 71034
Dresden, Germany
Status
Active, not recruiting
Address
Universitätsklinikum "Carl Gustav Carus", Zentrum für Klinische Neurowissenschaften
Dresden, , 01307
Düsseldorf, Germany
Status
Withdrawn
Address
Gemeinschaftspraxis für Neurologie; Dr. Katrin Schulte, Dr. Nils Richter, Dr. Margarete Capito
Düsseldorf, , 40211
Halle (Saale), Germany
Status
Withdrawn
Address
Krankenhaus Martha-Maria Hallo-Dölau, Klinik für Neurologie
Halle (Saale), , 06120
Hannover, Germany
Status
Withdrawn
Address
Medizinische Hochschule Hannover, Klinik für Neurologie
Hannover, , 30625
Jena, Germany
Status
Withdrawn
Address
Universitätsklinikum Jena, Klinik für Neurologie
Jena, , 07747
Kassel, Germany
Status
Withdrawn
Address
Neurologische Gemeinschaftspraxis Kassel und Vellmar, Ch. Lassek, Dres. Ammerbach, Fetzer, M. Fische
Kassel, , 34121
Kiel, Germany
Status
Active, not recruiting
Address
Universitätsklinikum Schleswig-Holstein; Klinik für Neurologie
Kiel, , 24105
Leipzig, Germany
Status
Active, not recruiting
Address
Universität Leipzig; Innere Medizin, Neurologie, Dermatologie
Leipzig, , 04103
Leipzig, Germany
Status
Completed
Address
PANAKEIA - Arzneimittelforschung Leipzig GmbH
Leipzig, , 04275
Marburg, Germany
Status
Withdrawn
Address
Universitaetsklinikum Marburg; Klinik fuer Neurologie
Marburg, , 35043
Trier, Germany
Status
Withdrawn
Address
Krankenhaus der Barmherzigen Brüder Trier; Neurologie, Neurophysiol. neurolog.Reha/Schlaganfalleinh
Trier, , 54292
Tübingen, Germany
Status
Active, not recruiting
Address
Universitätsklinikum Tübingen, Zentrum für Neurologie
Tübingen, , 72076
Ulm, Germany
Status
Active, not recruiting
Address
Universitätsklinikum Ulm; Klinik für Neurologie
Ulm, , 89081
Neuropraxis München Süd, Unterhaching, Germany
Status
Withdrawn
Address
Neuropraxis München Süd
Unterhaching, , 82008
Wiesbaden, Germany
Status
Active, not recruiting
Address
Deutsche Klinik für Diagnostik; DKD Helios Klinik Wiesbaden, Abt. Neurologie
Wiesbaden, , 65191
Athens, Greece
Status
Active, not recruiting
Address
401 Military Hospital of Athens; Neurology Department
Athens, , 115 25
Ioannina, Greece
Status
Withdrawn
Address
University General Hospital of Ioannina; Neurology Clinic
Ioannina, , 455 00
Larisa, Greece
Status
Withdrawn
Address
University General Hospital of Larisa; Neurology Clinic
Larisa, , 411 10
Thessaloniki, Greece
Status
Completed
Address
AHEPA Univ. General Hospital of Thessaloniki; B' Neurology Dept.
Thessaloniki, , 546 36
Bajcsy-Zsilinszky Hospital, Budapest, Hungary
Status
Withdrawn
Address
Bajcsy-Zsilinszky Hospital
Budapest, , 1106
S-Medicon Egeszsegugyi Szolgaltato Kft., Budapest, Hungary
Status
Active, not recruiting
Address
S-Medicon Egeszsegugyi Szolgaltato Kft.
Budapest, , 1138
UNO Medical Trials Kft., Budapest, Hungary
Status
Active, not recruiting
Address
UNO Medical Trials Kft.
Budapest, , 1152
Kaposvár, Hungary
Status
Active, not recruiting
Address
Somogy Megyei Kaposi Mor Oktato Korhaz; Department of Neurology
Kaposvár, , 7400
Ashkelon, Israel
Status
Withdrawn
Address
Barzilai Medical Center; Neurology Department
Ashkelon, , 7830604
Rambam Medical Center; Neurology Unit, Haifa, Israel
Status
Withdrawn
Address
Rambam Medical Center; Neurology Unit
Haifa, , 3109601
Hadassah University Hospital - Ein Kerem, Jerusalem, Israel
Status
Withdrawn
Address
Hadassah University Hospital - Ein Kerem
Jerusalem, , 9112001
Ramat-Gan, Israel
Status
Withdrawn
Address
The Chaim Sheba Medical Center; Multiple Sclerosis Center
Ramat-Gan, , 5262100
Tel Aviv, Israel
Status
Withdrawn
Address
Tel Aviv Sourasky Medical Center; Department of Neurology
Tel Aviv, , 6423906
Chieti, Abruzzo, Italy
Status
Active, not recruiting
Address
Universita? G. D'Annunzio; Dipartimento di Neuroscienze, Imaging e Scienze Cliniche
Chieti, Abruzzo, 66100
Napoli, Campania, Italy
Status
Active, not recruiting
Address
AOU Seconda Università degli Studi; Dip. Assistenziale Integrato Medicina Int-II Clinica Neurologica
Napoli, Campania, 80131
Napoli, Campania, Italy
Status
Active, not recruiting
Address
AOU Seconda Università degli Studi; Dip.Assistenziale Integrato Medicina Int-I Clinica Neurologica
Napoli, Campania, 80138
Roma, Lazio, Italy
Status
Active, not recruiting
Address
Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla
Roma, Lazio, 00133
NCL Institute Neuroscience, Roma, Lazio, Italy
Status
Active, not recruiting
Address
NCL Institute Neuroscience
Roma, Lazio, 00178
Roma, Lazio, Italy
Status
Active, not recruiting
Address
Policlinico Umberto I; Centro Sclerosi Multipla DAI Neuroscienze e Salute Mentale
Roma, Lazio, 00185
Milano, Lombardia, Italy
Status
Withdrawn
Address
Fondazione IRCCS CA GRANDA Ospedale Maggiore Policlinico; Centro Dino Ferrari, Div. di Neurologia
Milano, Lombardia, 20122
Milano, Lombardia, Italy
Status
Active, not recruiting
Address
Fond. Istituto Neurologico C.Besta; UO Neurologia IV - Neuroimmunologia Malattie Neuromuscolari
Milano, Lombardia, 20133
Pozzilli, Molise, Italy
Status
Active, not recruiting
Address
IRCCS Istituto Neurologico Neuromed; Centro per lo Studio e la Cura della Sclerosi Multipla
Pozzilli, Molise, 86077
Orbassano, Piemonte, Italy
Status
Withdrawn
Address
A.O. Universitaria S. Luigi Gonzaga Di Orbassano
Orbassano, Piemonte, 10043
Bari, Puglia, Italy
Status
Withdrawn
Address
Azienda Ospedaliero-Universitaria Consorziale Pol. di Bari; Neuroscienze e Organi di Senso
Bari, Puglia, 70124
Grupo Médico Camino S.C., Ciudad de México, Mexico CITY (federal District), Mexico
Status
Withdrawn
Address
Grupo Médico Camino S.C.
Ciudad de México, Mexico CITY (federal District), 03600
Clinstile S.A de C.V., Mexico City, Mexico CITY (federal District), Mexico
Status
Withdrawn
Address
Clinstile S.A de C.V.
Mexico City, Mexico CITY (federal District), 06700
Clinical Research Institute, Tlalnepantla de Baz, Mexico CITY (federal District), Mexico
Status
Withdrawn
Address
Clinical Research Institute
Tlalnepantla de Baz, Mexico CITY (federal District), 54055
Neurociencias Prisma, A.C, San Luis Potosí, SAN LUIS Potosi, Mexico
Status
Withdrawn
Address
Neurociencias Prisma, A.C
San Luis Potosí, SAN LUIS Potosi, 78216
Neurociencias Estudios Clinicos S.C., Culiacán, Sinaloa, Mexico
Status
Withdrawn
Address
Neurociencias Estudios Clinicos S.C.
Culiacán, Sinaloa, 80020
Guadalajara, Mexico
Status
Withdrawn
Address
Centro de Investigacion Medico Biologico y Terapia Avanzada, S.C.
Guadalajara, , 44130
Sittard-Geleen, Netherlands
Status
Withdrawn
Address
Zuyderland Medisch Centrum - Sittard Geleen
Sittard-Geleen, , 6162 BG
Arequipa, Peru
Status
Withdrawn
Address
Hospital Nacional Carlos Alberto Seguin Escobedo
Arequipa, , 54
Bellavista, Peru
Status
Active, not recruiting
Address
Hospital IV Alberto Sabogal Sologuren; Unidad de Investigacion
Bellavista, , Callao 2
Lima, Peru
Status
Active, not recruiting
Address
Clinica Internacional; Unidad De Investigacion
Lima, , 15001
Lima, Peru
Status
Active, not recruiting
Address
Hospital Nacional Dos de Mayo; Unidad de Investigacion de Neurologia
Lima, , 15003
Lima, Peru
Status
Active, not recruiting
Address
Instituto Nacional de Ciencias Neurológicas - Hospital Mogrovejo; Peru
Lima, , Lima 01
Hospital Maria Auxiliadora, Lima, Peru
Status
Active, not recruiting
Address
Hospital Maria Auxiliadora
Lima, , Lima 29
Clinica Sanchez Ferrer, Trujillo, Peru
Status
Active, not recruiting
Address
Clinica Sanchez Ferrer
Trujillo, , 13009
Neurocentrum Bydgoszcz sp. z o.o, Bydgoszcz, Poland
Status
Active, not recruiting
Address
Neurocentrum Bydgoszcz sp. z o.o
Bydgoszcz, , 85-796
Gdansk, Poland
Status
Active, not recruiting
Address
COPERNICUS Podmiot Leczniczy Sp. z o. o. Szpital im. M. Kopernika; Oddzia? Neurologiczny
Gdansk, , 80-803
MA-LEK Clinical Sp. Z o.o., Katowice, Poland
Status
Active, not recruiting
Address
MA-LEK Clinical Sp. Z o.o.
Katowice, , 40-595
Lodz, Poland
Status
Active, not recruiting
Address
SPZOZ Uniwersytecki Szp. Klin. nr1 im.N.Barlickiego UM;Oddzial Kliniczny Neurologii
Lodz, , 90-153
Centrum Neurologii Krzysztof Selmaj, Lodz, Poland
Status
Active, not recruiting
Address
Centrum Neurologii Krzysztof Selmaj
Lodz, , 90-324
Lublin, Poland
Status
Active, not recruiting
Address
Indywidualna Praktyka Lekarska Prof. Dr Hab. N. Med. Konrad Rejdak.
Lublin, , 20-016
Plewiska, Poland
Status
Active, not recruiting
Address
Neurologiczny Niepubliczny ZOZ Centrum Leczenia SM Osrodek Bada? Klinicznych
Plewiska, , 62-064
EMC Instytut Medyczny SA, Pozna?, Poland
Status
Active, not recruiting
Address
EMC Instytut Medyczny SA
Pozna?, , 60-309
Nzoz Palomed, Rzeszów, Poland
Status
Active, not recruiting
Address
Nzoz Palomed
Rzeszów, , 35-232
Osrodek Badan Klinicznych Euromedis, Szczecin, Poland
Status
Active, not recruiting
Address
Osrodek Badan Klinicznych Euromedis
Szczecin, , 70-111
Centrum Medyczne NeuroProtect, Warszawa, Poland
Status
Active, not recruiting
Address
Centrum Medyczne NeuroProtect
Warszawa, , 01-684
Warszawa, Poland
Status
Active, not recruiting
Address
Klinika Neurologii I Wydzialu Lekarskiego WUM w Warszawie
Warszawa, , 02-097
Warszawa, Poland
Status
Active, not recruiting
Address
Instytut Psychiatrii i Neurologii II Klinika Neurologiczna
Warszawa, , 02-957
Warszawa, Poland
Status
Active, not recruiting
Address
Wojskowy Instytut Medyczny - Pa?Stwowy Instytut Badawczy
Warszawa, , 04-141
Braga, Portugal
Status
Active, not recruiting
Address
Hospital de Braga; Centro Clínico Académico (Piso 1, Ala E)
Braga, , 4710-243
Lisboa, Portugal
Status
Active, not recruiting
Address
Centro Hospitalar de Lisboa Ocidental - Hospital Egas Moniz; Neurologia
Lisboa, , 1349-019
Lisboa, Portugal
Status
Active, not recruiting
Address
Hospital de Santa Maria; Servico de Neurologia
Lisboa, , 1649-035
Loures, Portugal
Status
Withdrawn
Address
Hospital Beatriz Angelo; Servico de Neurologia
Loures, , 2674-514
Krasnoyarsk, Krasnojarsk, Russian Federation
Status
Active, not recruiting
Address
FSBHI Siberian Clinical Center of the Federal Medical and Biological Agency
Krasnoyarsk, Krasnojarsk, 660037
Sankt-peterburg, Leningrad, Russian Federation
Status
Active, not recruiting
Address
National Center of Social Significant Disease
Sankt-peterburg, Leningrad, 197110
Neiro Clinica LLC, Moscow, Moskovskaja Oblast, Russian Federation
Status
Active, not recruiting
Address
Neiro Clinica LLC
Moscow, Moskovskaja Oblast, 117186
Research Center of Neurology of RAMS, Moscow, Moskovskaja Oblast, Russian Federation
Status
Active, not recruiting
Address
Research Center of Neurology of RAMS
Moscow, Moskovskaja Oblast, 125367
Moskva, Moskovskaja Oblast, Russian Federation
Status
Active, not recruiting
Address
Federal center of brain research and neurotechnologies
Moskva, Moskovskaja Oblast, 117997
Moskva, Moskovskaja Oblast, Russian Federation
Status
Active, not recruiting
Address
City Clinical Hospital #24; Multipal Sclerosis department
Moskva, Moskovskaja Oblast, 127015
Sankt-petersburg, Sankt Petersburg, Russian Federation
Status
Active, not recruiting
Address
N.P. Bechtereva Institute of the Human Brain
Sankt-petersburg, Sankt Petersburg, 197376
St. Petersburg, Sankt Petersburg, Russian Federation
Status
Active, not recruiting
Address
City Hospital #40 of Kurortniy Administrative District
St. Petersburg, Sankt Petersburg, 197706
Vertebronevrologiya LLC, Kazan, Tatarstan, Russian Federation
Status
Active, not recruiting
Address
Vertebronevrologiya LLC
Kazan, Tatarstan, 420047
Kazan, Tatarstan, Russian Federation
Status
Active, not recruiting
Address
KSMU Interregional Clinical Diagnostic Centre
Kazan, Tatarstan, 420101
Ulyanovsk Regional Clinical Hospital, Ulyanovsk, Uljanovsk, Russian Federation
Status
Active, not recruiting
Address
Ulyanovsk Regional Clinical Hospital
Ulyanovsk, Uljanovsk, 432063
Barnaul, Russian Federation
Status
Withdrawn
Address
State institution of health care - Territorial Clinical Hospital
Barnaul, , 656024
Ekaterinburg, Russian Federation
Status
Active, not recruiting
Address
SHI Sverdlovsk Regional Clinical Hospital #1;Neurology
Ekaterinburg, , 620102
Moscow, Russian Federation
Status
Withdrawn
Address
NSHI ?Central Clinical Hospital #2 of JSC "Russian Railways" n.a. N.A. Semashko?
Moscow, , 129128
Saratov, Russian Federation
Status
Active, not recruiting
Address
Saratov State Medical University of RosZdrav; Neurology
Saratov, , 410012
Nebbiolo Center for Clinical Trials, Tomsk, Russian Federation
Status
Active, not recruiting
Address
Nebbiolo Center for Clinical Trials
Tomsk, , 634009
Coruña, LA Coruña, Spain
Status
Active, not recruiting
Address
Complejo Hospitalario Universitario A Coruña (CHUAC); Servicio de Neurologia
Coruña, LA Coruña, 15006
Pozuelo de Alarcon, Madrid, Spain
Status
Active, not recruiting
Address
Hospital Quiron de Madrid; Servicio de Neurologia
Pozuelo de Alarcon, Madrid, 28223
Vigo, Pontevedra, Spain
Status
Active, not recruiting
Address
Hospital Alvaro Cunqueiro; Servicio de Neurologia
Vigo, Pontevedra,
Barcelona, Spain
Status
Active, not recruiting
Address
Hospital Universitari Vall d'Hebron; Servicio de Neumo-Inmunologia
Barcelona, , 08035
Cadiz, Spain
Status
Active, not recruiting
Address
Hospital Puerta del Mar; Sevicio de Neurologia
Cadiz, , 11009
Malaga, Spain
Status
Active, not recruiting
Address
Hospital Regional Universitario de Malaga ? Hospital General; Servicio de Neurologia
Malaga, , 29010
Aarau, Switzerland
Status
Withdrawn
Address
Kantonsspital Aarau AG Medizin Neurologie; Neurologie
Aarau, , 5001
Basel, Switzerland
Status
Active, not recruiting
Address
Universitätsspital Basel Medizin Neurologie; Neurologische Poliklinik
Basel, , 4031
Bern, Switzerland
Status
Active, not recruiting
Address
Inselspital Bern Medizin Neurologie; Neurologische Poliklinik
Bern, , 3010
Lugano, Switzerland
Status
Active, not recruiting
Address
Ospedale Regionale di Lugano - Civico; Neurologia
Lugano, , 6903
Gazi University Medical Faculty, Ankara, Turkey
Status
Withdrawn
Address
Gazi University Medical Faculty
Ankara, , 06500
Istanbul, Turkey
Status
Withdrawn
Address
Istanbul University Istanbul Medical Faculty; Neurology
Istanbul, , 34093
Istanbul, Turkey
Status
Withdrawn
Address
Istanbul Universitesi - Cerrahpasa Cerrahpasa Tip Fakultesi; Noroloji Anabilim Dali
Istanbul, , 34098
Istanbul, Turkey
Status
Withdrawn
Address
Sancaktepe Training and Research Hospital; Neurology
Istanbul, , 34785
Istanbul, Turkey
Status
Withdrawn
Address
Selcuk University Medical Faculty; Norology department
Istanbul, , 42131
Kocaeli, Turkey
Status
Active, not recruiting
Address
Kocaeli University Hospital; Department of Neurology
Kocaeli, , 41380
Ege Üniversitesi Tip Fakültesi, Lzmir, Turkey
Status
Withdrawn
Address
Ege Üniversitesi Tip Fakültesi
Lzmir, , 35100
Mersin, Turkey
Status
Withdrawn
Address
Mersin University Medical Faculty; Neurology
Mersin, , 33079
Samsun, Turkey
Status
Withdrawn
Address
Ondokuz Mayis University School of Medicine; Neurology
Samsun, , 55139
Trabzon, Turkey
Status
Withdrawn
Address
Karadeniz Tecnical Uni. Med. Fac.; Neurology
Trabzon, , 61080
Medical Center Dopomoga Plus, Kyiv, Chernihiv Governorate, Ukraine
Status
Active, not recruiting
Address
Medical Center Dopomoga Plus
Kyiv, Chernihiv Governorate, 02123
Zaporizhzhia, Katerynoslav Governorate, Ukraine
Status
Active, not recruiting
Address
Municipal Non-profit Enterprise Zaporizhzhya Regional Hospital Zaporizhzhya Regional Council
Zaporizhzhia, Katerynoslav Governorate, 69600
Zaporizhzhye, Katerynoslav Governorate, Ukraine
Status
Active, not recruiting
Address
Zaporizhia City Multispecialty Clinical Hospital #9
Zaporizhzhye, Katerynoslav Governorate, 69063
Kharkiv, Kharkiv Governorate, Ukraine
Status
Completed
Address
Municipal Nonprofit Enterprise of Kharkiv Regional Council Regional Clinical Hospital
Kharkiv, Kharkiv Governorate, 61058
Kyiv, KIEV Governorate, Ukraine
Status
Active, not recruiting
Address
Medical Center of Private Execution First Private Clinic
Kyiv, KIEV Governorate, 03037
Lvivska oblasna tsentralna likarnia, Lviv, KIEV Governorate, Ukraine
Status
Active, not recruiting
Address
Lvivska oblasna tsentralna likarnia
Lviv, KIEV Governorate, 79010
Miska Klinichna Likarnia ?16, Dnipropetrovsk, Tavria Okruha, Ukraine
Status
Active, not recruiting
Address
Miska Klinichna Likarnia ?16
Dnipropetrovsk, Tavria Okruha, 49100
Cherkasy, Ukraine
Status
Active, not recruiting
Address
Municipal Institution Cherkasy Regional Hospital of Cherkasy Regional Council
Cherkasy, , 18009
Chernihiv, Ukraine
Status
Active, not recruiting
Address
Mun.Med.Proph.Inst.?Chernihiv Reg.Hosp.?; Neurology Department
Chernihiv, , 14029
Bukovinsky SMU RMI Chernivtsi RCH, Chernivtsi, Ukraine
Status
Active, not recruiting
Address
Bukovinsky SMU RMI Chernivtsi RCH
Chernivtsi, , 58013
Ivano-Frankivsk, Ukraine
Status
Active, not recruiting
Address
Regional Clinical Hospital; Neurology Department
Ivano-Frankivsk, , 76008
Kharkov, Ukraine
Status
Active, not recruiting
Address
St.In.Inst. of Neurol.Psych.and Narcol.of the AMSU; Dept. of Neuroinfection and Multiply Sclerosis
Kharkov, , 61068
The Royal London Hospital, London, United Kingdom
Status
Withdrawn
Address
The Royal London Hospital
London, , E1 1FR
London, United Kingdom
Status
Withdrawn
Address
National Hospital for Neurology and Neurosurgery,; MRC Centre for Neuromuscular Diseases
London, , WC1 3BG
University of Nottingham, Nottingham, United Kingdom
Status
Withdrawn
Address
University of Nottingham
Nottingham, , NG7 2UH
Derriford Hospital, Plymouth, United Kingdom
Status
Active, not recruiting
Address
Derriford Hospital
Plymouth, , PL6 8BT
NARCOMS Patient Registry
Register as a willing MS research participant to facilitate multicenter studies. Initiated by the Consortium of MS Centers.
Posting a Trial
If you would like us to post a study on these pages, please email studies@nmss.org to find out what information you need to submit for review.