Accepts Healthy Volunteers
Healthy volunteers are participants who do not have a disease or condition, or related conditions or symptoms
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes.
An observational clinical study is where participants identified as belonging to study groups are assessed for biomedical or health outcomes.
Searching Both is inclusive of interventional and observational studies.
|Eligible Ages||18 Years - 65 Years|
More Inclusion & Exclusion Criteria
MS Patients Group:
- - between 18-65 years old; - diagnosed with mild or moderate disease (EDSS score ≤ 5 points); it meets the 2017 new version of McDonald diagnostic criteria for multiple sclerosis.
- - meet the diagnostic criteria of clinically isolated syndromes (CIS)
Exclusion Criteria:- No brain surgery/no brain trauma/no history of brain disease (stroke), no other independent neurological or psychiatric history; - No severe depression symptoms; - No alcoholism or drug dependence (addiction); - No other conditions that affect the smooth progress of the inspection: such as hearing impairment, comprehension impairment, poor compliance, etc.; - No rheumatic diseases and other acute or chronic inflammations (required for hematological markers).
- - No MR contrast agent allergy.
- - between 18-65 years old;
- able to understand the purpose of clinical research and test plan;
- In the brain MR assessment, it is judged as "normal (corresponding to age)"
Exclusion Criteria:- Any major mental illness; history of schizophrenia or schizoaffective disorder.
This trial id was obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health, providing information on publicly and privately supported clinical studies of human participants with locations in all 50 States and in 196 countries.
Phase 1: Studies that emphasize safety and how the drug is metabolized and excreted in humans.
Phase 2: Studies that gather preliminary data on effectiveness (whether the drug works in people who have a certain disease or condition) and additional safety data.
Phase 3: Studies that gather more information about safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs.
Phase 4: Studies occurring after FDA has approved a drug for marketing, efficacy, or optimal use.
The sponsor is the organization or person who oversees the clinical study and is responsible for analyzing the study data.
The person who is responsible for the scientific and technical direction of the entire clinical study.
|Principal Investigator Affiliation||N/A|
Category of organization(s) involved as sponsor (and collaborator) supporting the trial.
The disease, disorder, syndrome, illness, or injury that is being studied.
Arms & Interventions
Experimental: MS Patients Group
Sham Comparator: Healthy Volunteers Group
Diagnostic Test: - 18F-florbetapir PET+MRSI
PET and MRS quantitative parameters in MS lesions are simultaneously analyzed using hybrid PET/MR for obtaining demyelination and neuronal damage information.
Contact a Trial Team
If you are interested in learning more about this trial, find the trial site nearest to your location and contact the site coordinator via email or phone. We also strongly recommend that you consult with your healthcare provider about the trials that may interest you and refer to our terms of service below.