• - PATIENT INCLUSION CRITERIA (for in-person and telemedicine sub-cohorts): Presentation with a clinical syndrome consistent with immune-mediated CNS disorder and/or.

Neuroimaging evidence of inflammatory and/or demyelinating/ dysmyelinating CNS disease. At least 12 years old at the time of enrollment. Willing to share medical records (including past MRI results) with the study team. Adults: Able to give informed consent on their own or via a Legally Authorized Representative (LAR) or Durable Power of attorney (DPA), or Minors: parent or legal guardian able to give consent, with child willing to give assent, if reasonable based on their age and assent capacity, able to give assent with consent given by their parent or legal guardian. For in-person sub-cohort: Able to undergo the required procedures, including LP, MRI and clinical/functional evalautions. HEALTHY VOLUNTEER (in person)

INCLUSION CRITERIA:

At least 18 years old at the time of enrollment. Vital signs are found within normal range at the time of the screening visit. Able to give informed consent. Able and willing to undergo related research procedures, such as blood draw, LP. PATIENT INCLUSION CRITERIA for processing of collected biological samples: Presentation with a clinical syndrome consistent with immune-mediated CNS disorder and/or. Neuroimaging evidence of inflammatory and/or demyelinating/ dysmyelinating CNS disease. Ability to obtain either direct or surrogate informed consent for sample processing and storage. Aged 0+ years. PATIENT EXCLUSION CRITERIA (for in-person and telemedicine subcohorts): Significant medical condition that would make participation in diagnostic and research part of evaluation impossible or risky. For in-person sub-cohort: Medical contraindications for MRI (ie- any non-organic implant or other device such as a cardiac pacemaker or infusion pump or other metallic implants, objects or body piercings that cannot be removed) Unable to provide informed consent. Unwilling to consent for collection of biological samples or their cryopreservation. HEALTHY VOLUNTEER (in person)

EXCLUSION CRITERIA:

Systemic inflammatory disorder or inflammatory or non-inflammatory nurological diseases. Previous or current history of alcohol and substance abuse. Medical contraindications for MRI (i.e. any non-organic implant or other device such as a cardiac pacemaker or infusion pump or other metallic implants, objects or body piercings that cannot be removed) Medical contraindication for LP. Psychological contraindications for MRI (i.e. claustrophobia). This will be assessed at the time the medical history is collected. Pregnancy or current breastfeeding. Any contraindications to having study procedures done History of auditory disorder (i.e. hearing impairment, known impaired acoustic reflex, tinnitus) HEALTHY VOLUNTEER SUB STUDY TO OBTAIN NORMATIVE DATA FOR THE SMARTPHONE APPS: Because this sub study collects no personal identifiable information (PII), there are no inclusion/exclusion criteria. Participating subjects are self-declared as not having any neurological deficit, which would be the same population that would provide normative data if the apps were freely available via App store.

The goal of this study is to define the pathophysiological mechanisms underlying the development of disability in immune-mediated disorders of the central nervous system (CNS) and to distinguish these from beneficial responses of the human immune system to CNS injury. The protocol serves as a screening tool for Neuroimmunological Diseases Section (NDS) of the National Institute of Allergy and Infectious Diseases (NIAID) clinical trials and enables development of clinically-useful tools such as diagnostic tests and new, sensitive scales of neurological disability, disease severity and CNS tissue destruction. This protocol also serves as a repository to enable prospective institutional review board (IRB) review of research using human samples and data collected under other NDS protocols.

Arms

: Healthy Volunteer

Healthy patients with NO inflammatory and/or demyelinating/dysmyelinating diseases of the CN

: Patient Cohort

Patients who present with CNS white matter injury (including inflammatory and/or demyelinating/dysmyelinating diseases of the CNS)

Interventions